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1. The intestinal microbiota

We are 90% bacterial and 10% human.

 

The human digestive tract is a complex ecosystem, that is home to millions of microorganisms and hundreds of different types of bacteria. The human microbiome consists of ten times more microbial than human cells, i.e., 100 billion. Our gut flora contains more than three million microbial genes, or 150 times more genes than in the human genome. More than 1,000 different known bacterial species can be found in human gut microbiota but only 150 to 170 predominate in any given subject.

 

Most gut microbes are harmless or even beneficial to the host. They protect against stomach and intestinal pathogens (the bacteria that cause food-borne infections), help extract nutrients and energy from food and contribute to normal immune function. Some of these bacteria may be potentially dangerous. But they are usually kept in check by good bacteria to maintain the so-called microbiota balance.

 

A microbial imbalance can trigger infections with opportunistic pathogens, causing various episodes of diarrhoea for example.

Disruptions of this delicate balance are linked to obesity, malnutrition, unhealthy eating, illness, stress, etc.. A microbial imbalance can also trigger infections with opportunistic pathogens, causing various episodes of diarrhoea for example. Various factors can disrupt the microbial balance in the intestine, such as the use of medicines in case of illness, e.g., antibiotics. Treatments with antibiotics partly destroy microbial populations, the commensal microbiota is decreased, creating an environment that is susceptible to pathogenic and opportunistic intruders.

 

Dysbiosis of intestinal microbiota can also be caused by pathogenic (bacterial) infections such as listeria and salmonella.

 

Diarrhoea can be caused by viral infections such as the rotavirus and infections.

Digest Plus strains

 

Lactobacillus rhamnosus GG ATCC 53103 inhibits the growth of pathogenic bacteria such as Listeria spp or Salmonella spp. in vitro. These effects were observed in vivo, in at least two recent independent clinical studies (one in Caucasian infants and another with an Asian population of allergic adults), which showed that the consumption of Lactobacillus rhamnosus GG ATCC 53103 increases the wealth of Lactobacillus, butyrogenic bacteria such as Ruminococcus and the diversity of the microbiota in general. These studies also showed that Lactobacillus rhamnosus GG ATCC 53103 reduces the numbers of potential enteropathogens such as Escherichia.2

 

Lactobacillus rhamnosus GG ATCC 53103 was confirmed to reduce the duration of diarrhoea.4

 

Digest Plus strains are homofermentative bacteria3. Unlike heterofermentative bacteria, they do NOT produce CO2 and ethanol as the end product of the metabolism of simple sugars, such as glucose or fructose, which is seen as a negative effect. Ethanol can influence gastric motility as gas production can result in bloating and flatulence.

 

Lactobacillus rhamnosus GG ATCC 53103 also inhibits the dysbiosis caused by antibiotic treatments with penicillin5. The presence of the Bifidobacterium longum CECT7894 strain is very relevant to achieve healthy numbers of bifidobacteria.6

 

Moreover, the probiotic strains Bifidobacterium longum CECT7894 and Pediococcus pentosaceus CECT8330 have shown that they are able to inhibit the growth of potentially pathogenic bacteria, such as Escherichia coli and other of the Enterobacter, Klebsiella and Bacteroides species in vitro. A clinical study showed that the numbers of enterobacteria had decreased and that the numbers of bifidobacteria had increased significantly after a daily dose of the two probiotic strains Bifidobacterium longum CECT7894 and Pediococcus pentosaceus CECT8330 over a period of two weeks.6

 

Sources:
2 Segers ME, Lebeer S. Towards a better understanding of Lactobacillus rhamnosus GG - host interactions. Microbial Cell Factories. 2014;13(Suppl 1):S7-S23.
3 Santas J et al. Pediococcus pentosaceus CECT 8330 and Bifidobacterium longum CECT 7894 show a trend towards lowering infantile excessive crying syndrome in a pilot clinical trial. Int J Pharma Bio Sci 2015; 6(2):P458–66.
4 Szajewska H, Skórka A, Ruszczyński M, Gieruszczak-Białek D. Meta-analysis: LactobacillusGG for treating acute gastroenteritis in children--updated analysis of randomised controlled trials. Aliment Pharmacol Ther. 2013 Sep;38(5):467–76.
5 Szajewska H, Kołodziej M. Systematic review with meta-analysis: Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea in children and adults. Aliment Pharmacol Ther. 2015 Nov;42(10):1149–57.
6 Tintore M et al. (2017) Gut Microbiota Dysbiosis and Role of Probiotics in Infant Colic. Arch Clin Microbiol. Vol. 8 No. 4:56 doi:10.4172/1989-8436.100056

 

 

Treatment of diarrhea with Pur Natur bio activ yogurt

 

Fig1: Lactobacillus Rhamnosus GG reduces the incidence of diarrhoea. A: the number of acute diarrhoeal cases was reduced by 400% in the Lactobacillus Rhamnosus GG group vs. the placebo group. B: the incidence of diarrhoea caused by the rotavirus was 9 times lower in patients treated with Lactobacillus Rhamnosus GG compared with the placebo group. C: the duration of the diarrhoea was reduced by 32% when Lactobacillus Rhamnosus GG was used as a supplement during rehydration. D: the incidence of AAD (antibiotic associated diarrhoea) was 9 times lower in the Lactobacillus Rhamnosus GG group compared with the placebo group.

Graph source:
6 Tintore M et al. (2017) Gut Microbiota Dysbiosis and Role of Probiotics in Infant Colic. Arch Clin Microbiol. Vol. 8 No. 4:56 doi:10.4172/1989-8436.100056

 

Helps rebalance the microbiota with Pur Natur bio activ yogurt 

 

Fig2: Antagonistic effect of P. pentosaceus CECT 8330 and B. longum CECT 7894 against pathogenic bacteria. The effect of B. longum CECT 7894 is probably greater, although the methodology was unable to further detect this.

Graph source:
7 Szajewska H et al. Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants. J Pediatr 2001; 138: 361-5.
8 Canani RB et al. Probiotics for treatment of acute diarrhoea in children:randomised clinical trial of five different preparations. BMJ 2007; 335: 340-5.
9 Arvola T, Laiho K, Torkkeli S, Mykkänen H, Salminen S, Maunula L, Isolauri E. Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomized study. Pediatrics. 1999 Nov;104(5):e64.

 

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